Categories: 药物输送系统

口腔癌和纳米技术的治疗方法。从基本概念、发病率、分子机制到新兴的治疗技术

回顾[1]。口腔癌是最普遍的,致死率大,攻击性强的癌症,在攻击其他组织时可引起转移。癌的流行是一个多步骤的方法,需要收集许多受患者遗传易感性和环境影响的遗传变化,包括尼古丁、酒精饮料、慢性感染和病毒污染。通过各种搜索引擎和Pubmed数据库,使用焦点关键词搜索数据,包括口腔癌、分子机制、治疗和纳米技术。有两种主要的致癌基因操作类型,即肿瘤抑制基因和致癌基因。肿瘤抑制基因可以在整个遗传现象中失活,如突变、异质性丧失、缺失或表观遗传学改变,如DNA的甲基化或染色质的动态修改。肿瘤基因可以通过基因扩增导致的过量表达、转录增强或突变导致的结构变化而被激活,从而导致转化活性增强。目前的审查重点是利用纳米药物加强癌症治疗技术,包括纳米级药物转移系统的设计、特性、生产和利用。用于诊断调查的仪器和医疗设备是基于纳米技术的治疗方法,包括聚合物纳米颗粒、纳米结构的脂质载体、金纳米颗粒和环糊精复合物,这些都是有希望用于症状测试和帮助治疗的仪器。

这篇评论的重点是石墨烯纳米颗粒而不是CD。一些关于CD应用的论文本来是值得一提的:利多卡因/HPBCD[2],氯素e6/HPBCD[3],以及一篇评论[4]。

[1] Dan, S., Upadhyay, S.K., Girdhar, M., Mandal, M., Sakshi (2022) Oral carcinoma and therapeutic approaches of nanotechnology: From fundamental concepts, incidence, molecular mechanism to emerging treatment techniques. Biointerface Research in Applied Chemistry 12(3), 3900-3937. https://doi.org/10.33263/BRIAC123.39003937

[2] Luiz E N Ferreira, Gabriela B M Antunes, Bruno V Muniz, Jonny Burga-Sánchez, Nathalie F S de Melo, Francisco C Groppo, Leonardo F Fraceto, Maria C Volpato (2018) Effects of lidocaine and the inclusion complex with 2-hydroxypropyl-β-cyclodextrin on cell viability and proliferation of oral squamous cell carcinoma. Journal of Pharmacy and Pharmacology, 70, 874–882, https://doi.org/10.1111/jphp.12917

[3] Shubhajit Paul, Paul Wan Sia Heng, Lai Wah Chan (2016) pH-dependent complexation of hydroxypropyl-beta-cyclodextrin with chlorin e6: effect on solubility and aggregation in relation to photodynamic efficacy. Journal of Pharmacy and Pharmacology, 68, 439–449, https://doi.org/10.1111/jphp.12535

[4] Gharat, S. A., Momin, M., & Bhavsar, C. (2016). Oral Squamous Cell Carcinoma: Current Treatment Strategies and Nanotechnology-Based Approaches for Prevention and Therapy. Critical Reviews™ in Therapeutic Drug Carrier Systems, 33(4), 363–400. https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2016016272

Japanese cyclodextrin researcher

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