Categories: 药物输送系统

对比剂(closo-dodecaiododecaborate)封装在HP-γ-CD中可防止溶血

Na2B12I12具有X射线造影剂所需的许多特性,但在医学成像所需的浓度下是致命的。我们在此证明,含有>50 mM Na2B12I12的PBS溶液会诱发溶血,这与之前报道的阴离子的超混杂性质一致。<1当量的2-羟基丙基-γ-环糊精的存在可以防止溶血,并提出了利用B12I122-作为X射线对比剂的策略。

Sophia E. Hollowa and Timothy C. Johnstone (2022) Encapsulation of closo-dodecaiodododecaborate in 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis. Chem. Commun. First published19 Jan 2022. https://doi.org/10.1039/D1CC06348K

Japanese cyclodextrin researcher

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