2021年8月12日
在以前的研究中，已经证明了用β-环糊精珠子聚合物（BBP）从水溶液（包括某些饮料）中提取霉菌毒素alternariol, zearalenone, zearalenols, zearalenone-14-glucoside和zearalenone-14-sulfate[1-5] 。在最近的一项调查中，还对BBP诱导的12种霉菌毒素进行了测试，包括黄曲霉毒素B1、黄曲霉毒素M1、柠檬酸、二氢柠檬酸、环孢菌素、脱氧雪腐镰刀菌烯醇、赭曲霉毒素A、棒曲霉毒素、赤霉烯酮、α-泽兰醇和β-泽兰醇[6]。BBP对脱氧雪腐镰刀菌素、黄曲霉毒素M1和棒曲霉毒素的结合力较弱，对黄曲霉毒素B1和环嗪酸的结合力中等，而BBP被证明对柠檬素、二氢柠檬素、立体孢子菌素、玉米赤霉烯酮、α-泽兰醇和β-泽兰醇的结合力强。环境的pH值（在pH3.0和pH7.0之间测试）对BBP的霉菌毒素结合能力没有很大影响，只有赭曲霉毒素A在pH3.0时才被有效提取。这项研究强调BBP可能适合于去除/提取霉菌毒素，例如用于净化和/或分析目的。
参考文献:
[1] Fliszár-Nyúl E, Lemli B, Kunsági-Máté S, Szente L, Poór M (2019) Interactions of mycotoxin alternariol with cyclodextrins and its removal from aqueous solution by beta-cyclodextrin bead polymer. Biomolecules 9:428. https://doi.org/10.3390/biom9090428
[2] Fliszár-Nyúl E, Szabó Á, Szente L, Poór M (2020) Extraction of mycotoxin alternariol from red wine and from tomato juice with betacyclodextrin bead polymer. J Mol Liq 319:114180. https://doi.org/10.1016/j.molliq.2020.114180
[3] PoórM, Faisal Z, Zand A, Bencsik T, Lemli B, Kunsági-Máté S, Szente L (2018) Removal of zearalenone and zearalenols from aqueous solutions using insoluble beta-cyclodextrin bead polymer. Toxins 10:216. https://doi.org/10.3390/toxins10060216
[4] Faisal Z, Fliszár-Nyúl E, Dellafiora L, Galaverna G, Dall’Asta C, Lemli B, Kunsági-Máté S, Szente L, Poór M (2019) Cyclodextrins can entrap zearalenone-14-glucoside: interaction of the masked mycotoxin with cyclodextrins and cyclodextrin bead polymer. Biomolecules 9:354. https://doi.org/10.3390/biom9080354
[5] Faisal Z, Fliszár-Nyúl E, Dellafiora L, Galaverna G, Dall’Asta C, Lemli B, Kunsági-Máté S, Szente L, Poór M (2020) Interaction of zearalenone-14-sulfate with cyclodextrins and the removal of the modified mycotoxin from aqueous solution by beta-cyclodextrin bead polymer. J Mol Liq 310:113236. https://doi.org/10.1016/j.molliq.2020.113236
[6] Mohos V, Faisal Z, Fliszár-Nyúl E, Szente L, Poór M (2021) Testing the extraction of 12 mycotoxins from aqueous solutions by insoluble beta-cyclodextrin bead polymer. Environ. Sci. Pollut. Res. (Published online) https://doi.org/10.1007/s11356-021-15628-1
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